The HARPdoc programme has been tested in a clinical trial in which consenting participants, all adults with type 1 diabetes and problematic hypoglycaemia persisting despite otherwise optimised control, were randomly assigned to HARPdoc or to an alternative programme, Blood Glucose Awareness Training or BGAT, that does not specifically address thoughts and health beliefs about hypoglycemia and its avoidance. The trial (ClinicalTrials.gov NCT02940873) was funded by the Juvenile Diabetes Research Foundation and ran from 2017 to 2021. From this page you can access the peer-reviewed scientific papers that have been published by the triallists and associated researchers. Click on a link to read the paper.
A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)
Cognitions Associated With Hypoglycemia Awareness Status and Severe Hypoglycemia Experience in Adults With Type 1 Diabetes in which nearly 2000 US adults with type 1 diabetes describe their thoughts about hypoglycaemia
HARPdoc: protocol for a group randomised controlled trial of a novel intervention addressing cognitions in which the protocol for the trial is described, including background for the trial and the methods used
Effectiveness-implementation hybrid type 2 trial evaluating two psychoeducational programmes for severe hypoglycaemia in type 1 diabetes: implementation study protocol describing an implementation science study
Hypoglycemia Subtypes in Type 1 diabetes: An Exploration of the Hypoglycemia Fear Survey II describes fear of hypoglycaemia and thoughts around its avoidance and their interaction with problematic hypoglycaemia
Characteristics of adults with type 1 diabetes and treatment-resistant problematic hypoglycaemia: A baseline analysis from the HARPdoc RCT finds high mental health burden for people enrolling in the HARPdoc trial
A psychoeducational program to restore hypoglycemia awareness: the DAFNE-HART pilot study